SiSiB® PC9210 (also called as Bis(trimethylsilyl)amine; HMDS; HMDZ) is an extremely versatile and strong silylating agent. It is primarily used for the protection of sensitive functional groups during chemical synthesis.
Trimethylsilyl moiety silazane is a versatile blocking agent employed in chemical synthesis. Introduction of silyl protective groups has following advantages.
Masking of reactive functional groups.
Improvement of solubility in polar and or non polar solvent.
Improved product stability.
Easy removal of protective groups .
Additional activation of reactive centres.
Easyelimination of hydrogen bonds.
One of the advantages of SiSiB® PC9210 over other organo silanes is that no base is needed as a hydrochloric acid acceptor. SiSiB® PC9210 produces ammonia which escapes easily from the reaction mixture during silylation.
For the price of HMDS/HMDZ chemical and other relevant information, please feel free to contact us.
Color and Appearance
Clear colorless liquid
SiSiB® PC9210 hexamethyldisilazane silylating agent can be used to introduce trimethylsilyl group into organic molecules containing an active hydrogen atom such as alcohols, carboxylic acids, amines etc. The most common industrial application of SiSiB® PC9210 hexamethyldisilazane is in production of semi synthetic beta lactum antibiotics as ampicillin and cephalexin.
The usual procedure is to protect the carboxylic group in the antibiotic with HDMS followed by acylation with the desired acylchloride. Finally, desilylation under mild aqueous conditions gives the desired product.
SiSiB® PC9210 is supplied in 150Kg steel drum.
In the unopened original container SiSiB® PC9210 has a shelf life of one year in a dry and cool place.